Evolution of tumor microenvironment in colorectal liver metastases under treatment stress

作     者：Na Huang Dongqiang Zeng Xiaoxiang Rong Chunlin Wang Zhenzhen Wu Jian Guo Yuqi Wang Jin Li Jing Li Jiao Wang Siting Zheng Genjie Huang Jianping Bin Yulin Liao Qian Li Xin Yi Wangjun Liao Min Shi 

作者机构：Department of OncologyNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515P.R.China Department of Research and DevelopmentGenePlus-BeijingBeijing 102206P.R.China Department of CardiologyNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515P.R.China 

出 版 物：《Cancer Communications》 (癌症通讯（英文）)

年 卷 期：2022年第42卷第5期

页      面：471-475页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by grants from the National Natural Science Foundation of China(81772580) Natural Science Foundation of Guangdong Province,China(2021A1515011705) the Clinical Research Startup Program of Southern Medical University by High-level University Construction Funding of Guangdong Provincial Department of Education(LC2016ZD014) 

主　　题：colorectal metastases treatment 

摘      要：Dear editor,The tumor microenvironment(TME)heavily impacts disease biology and may influence responses to systemic treatments,and thereby,affects patients’*** our previous study,we found that immune features could predict prognosis and guide the therapy choices for stage I-III colon cancer[1,2].Increasing evidence shows that therapyinduced TME changes can promote tumor progression,metastasis,and the development of resistance[3,4].However,the TME dynamics in colorectal liver metastases(CRLM)under treatment are still incompletely clear.