The preventive and therapeutic potential of native Brazilian fruits on colorectal cancer
作者机构：University of CampinasSchool of Food EngineeringMonteiro Lobato Street 8013083-862CampinasS˜ao Paulo stateBrazil
出 版 物：《Food Bioscience》 (食品生物科学（英文）)
年 卷 期：2022年第46卷第2期
页 面：55-72页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Special thanks to 1.Paula Januzzi Guedes,a self-employed design professional responsible for creating the figures,and 2.Red Iberomericana de Alimentos Autoctonos Subutilizados(ALSUB-CYTED,118RT0543) This study was partly funded by Conselho Nacional de Desenvolvimento Científico e Tecnol´ogico(CNPq)-Processes 140812/2019-9,403328/2016-0,and 301496/2019-6 3.Fundaç˜ao de Amparo`a Pesquisa do Estado de S˜ao Paulo(FAPESP)-Processes 15/50333-1,15/13320-9,17/23657-6,18/11069-5,19/25048-2,and 19/03228-9
主 题：Anthocyanin Bioactive compound Carcinogenesis Euterpe oleracea Phenolic compound Theobroma cacao
摘 要：In the last years,colorectal cancer(CRC)has been increasing substantially in developing *** the consumption of fat and meat have been linked with increased CRC risk,fruits intake can be *** addition,since CRC’s chemotherapy may be accompanied with adverse effects,natural plant products have been postulated as alternative or complementary therapeutic *** fruits are rich sources of bioactive compounds,mainly phenolic compounds,with antioxidant,anti-inflammatory,and anticancer benefits,thus,future candidates for CRC ***,this narrative review aims to present and discuss the potential of native Brazilian fruits(e.g.,açaí,cocoa,jaboticaba,passionfruit)on *** studies performed from 2001 to present were ***-rich powders and extracts from Brazilian fruits are the most promising products for CRC *** with açaí(Euterpe oleracea)and cocoa(Theobroma cacao)are more numerous and their effects on CRC models in vitro and in vivo are demonstrated with more complexity in terms of molecular *** main signaling pathways modulated by the effects of native Brazilian fruits,so far studied on CRC,are associated with:***(B-cell lymphoma 2-and caspase 3-related proteins),***(pro-inflammatory interleukins and enzymes),and *** stress(antioxidant enzymes).In addition,adhesion molecules and nuclear factor kappa B have been shown to be downregulated,which can interfere positively in several cellular processes,including proliferation,angiogenesis,and *** investigation of signaling pathways of great relevance for CRC initiation and progression is still necessary.
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