Chronic traumatic encephalopathy: genes load the gun and repeated concussion pulls the trigger

作     者：Robert Vink Frances Corrigan Robert Vink;Frances Corrigan

作者机构：Clinical and Health SciencesUniversity of South AustraliaAdelaideSAAustralia Adelaide Medical SchoolUniversity of AdelaideAdelaideSAAustralia 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第9期

页      面：1963-1964页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported in part by a grant from the National Health and Medical Research Council of Australia 

主　　题：traumatic encephalopathy impairment 

摘      要：The association between traumatic brain injury(TBI)and an increased risk of neurodegeneration has been recognized for some decades now(Faden and Loane,2015),with recent evidence suggesting that a history of TBI,either as repeated concussive/mild TBI insults typically experienced by some athletes or less commonly as a single moderate/severe injury,may be linked with an increased risk of developing a specific form of neurodegeneration known as chronic traumatic encephalopathy(CTE)(McKee et al.,2016).The pathognomonic lesions of CTE are hyperphosphorylated tau aggregates,initially in neurons and astrocytes close to blood vessels at the base of the sulci,but later spreading throughout the brain(McKee et al.,2016).Recent work has focused on developing diagnostic criteria for traumatic encephalopathy syndrome,the clinical disorder associated with CTE,which is thought to encompass cognitive impairment and/or neurobehavioral impairment characterized by explosiveness,impulsivity and emotional lability(Katz et al.,2021).