Multifunctional inorganic nanomaterials for cancer photoimmunotherapy
作者机构：State Key Laboratory of Natural MedicinesDepartment of PharmaceuticsSchool of PharmacyChina Pharmaceutical UniversityNanjingJiangsuP.R.China National Medical Products Administration Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and ExcipientsChina Pharmaceutical UniversityNanjingJiangsuP.R.China
出 版 物：《Cancer Communications》 (癌症通讯（英文）)
年 卷 期：2022年第42卷第2期
页 面：141-163页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：support from National Nature Science Foundation of China(Nos.31872756 and 32071387)
主 题：biodegradability cancer photoimmunotherapy immune stimulation inorganic nanomaterial nanoparticles targeted drug delivery
摘 要：Phototherapy and immunotherapy in combination is regarded as the ideal ther-apeutic modality to treat both primary and metastatic ***-apy uses different immunological approaches to stimulate the immune system to identify tumor cells for targeted *** destroys the pri-mary tumors by light irradiation,which induces a series of immune responses through triggering immunogenic cancer cell ***,when integrat-ing immunotherapy with phototherapy,a novel anti-cancer strategy called pho-toimmunotherapy(PIT)is *** synergistic treatment modality can not only enhance the effectiveness of both therapies but also overcome their inherent limitations,opening a new era for the current anti-cancer ***,the advancement of nanomaterials affords a platform for *** all these nanomaterials,inorganic nanomaterials stand out as idealmediators in PIT due to their unique physiochemical *** nanomaterials can not only serve as carriers to transport immunomodulatory agents in immunotherapy owing to their excellent drug-loading capacity but also function as photother-mal agents or photosensitizers in phototherapy because of their great optical *** this review,the recent advances of multifunctional inorganic nanomaterial-mediated drug delivery and their contributions to cancer PIT will be highlighted.
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