Role of ethanol in the regulation of hepatic stellate cell function
Role of ethanol in the regulation of hepatic stellate cell function作者机构：Storr Liver Unit Westmead Millennium Institute University of Sydney and WestmeadHospital Westmead New South Wales Australia Drug and Alcohol Clinical Services HunterNew England Area Health Service Locked Bag 119 WallsendNew South Wales 2287 Australia
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2006年第12卷第43期
页 面：6926-6932页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Ethanol Acetaldehyde Hepatic stellate cells liver fibrosis Type I collagen gene Transcription factors Transforming growth factor β-1
摘 要：Evidence has accumulated to suggest an important role of ethanol and/or its metabolites in the pathogenesis of alcohol-related liver disease. In this review, the fibrogenic effects of ethanol and its metabolites on hepatic stellate cells (HSCs) are discussed. In brief, ethanol interferes with retinoid metabolism and its signaling, induces the release of fibrogenic cytokines such as transforming growth factor β-1 (TGFβ-1) from HSCs, up-regulates the gene expression of collagen I and enhances type I collagen protein production by HSCs. Ethanol further perpetuates an activated HSC phenotype through extracellular matrix remodeling. The underlying pathophysiologic mechanisms by which ethanol exerts these pro-fibrogenic effects on HSCs are reviewed.
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