Recent advancements toward non-invasive imaging of retinal amyloid-beta for early detection of Alzheimer’s disease

作     者：Liang Wang Xiaobo Mao Liang Wang;Xiaobo Mao

作者机构：University of Miami Miller School of MedicineMiamiFLUSA Neuroregeneration and Stem Cell ProgramsInstitute for Cell EngineeringDepartment of NeurologyJohns Hopkins University School of MedicineBaltimoreMDUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第8期

页      面：1741-1742页

核心收录：

学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学] 

基　　金：funded by NIH R01 NS107318 NIH K01 AG056841 American Parkinson’s Disease Association,Parkinson’s Foundation the Stanley Fahn Junior Faculty Award PF-JFA-1933 Maryland Stem Cell Research Foundation Discovery Award 2019-MSCRFD-4292 

主　　题：amyloid Alzheimer routine 

摘      要：Alzheimer’s disease(AD)is a neurodegenerative disorder characterized by progressive cognitive impairment suggested to be induced by the accumulation of amyloid-β(Aβ)in the brain,especially in the *** Aβdeposits may be detected through positron emission tomography(PET)as early as two decades before clinically diagnosed AD-associated dementia,which provides the opportunity for early therapeutic interventions(Wang and Mao,2021).PET may not be suitable for AD screening since it is invasive,costly,and inaccessible for routine clinical use or population screening.Aβdeposits have also been identified throughout the retina,which is a developmental outgrowth of the diencephalon and shares physiological and pathological pathways with the central nervous system(London et al.,2013).Patients with mild cognitive impairment and early AD are reported to have visual disturbances involving visual field loss with reported thinning of the retinal layers including the retinal nerve fiber layer,ganglion cell layer,and inner plexiform layer(Koronyo-Hamaoui et al.,2011;Wang and Mao,2021).Retinal Aβdeposits have been detected prior to the manifestation of cerebral Aβdeposits in transgenic mice models of AD(Koronyo-Hamaoui et al.,2011;Habiba et al.,2021).Since the retina provides an easily accessible location for non-invasive imaging,retinal Aβmay have the potential to be a surrogate for cerebral Aβand a biomarker for the detection of AD prior to irreversible cognitive impairment.