Peroxidase from foxtail millet bran exerts anticolorectal cancer activity via targeting cellsurface GRP78 to inactivate STAT3 pathway

作     者：Shuhua Shan Jinping Niu Ruopeng Yin Jiangying Shi Lizhen Zhang Caihong Wu Hanqing Li Zhuoyu Li 

作者机构：Institute of BiotechnologyKey Laboratory of Chemical Biology and Molecular Engineering of National Ministry of EducationShanxi UniversityTaiyuan 030006China School of Life ScienceShanxi UniversityTaiyuan 030006China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2022年第12卷第3期

页      面：1254-1270页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by National Natural Science Foundation of China(Nos.31500630,31770382,32072220,and 81803238) “1331 Project”Key Innovation Center and Team,National Key Research and Development Project(No.2020YFD1001405,China) Shanxi Key Laboratory for Research and Development of Regional Plants,Higher Education Institution Project of Shanxi Province:Ecological Remediation of Soil Pollution Disciplines Group(No.20181401,China) the Open Project Program of Xinghuacun College of Shanxi University[Shanxi Institute of Brewing Technology and Industry(Preparation)](No.XCSXUKF-202004,China) 

主　　题：Foxtail millet bran FMBP csGRP78 STAT3 ROS Colorectal cancer 

摘      要：Molecular targeted therapy has become an emerging promising strategy in cancer treatment,and screening the agents targeting at cancer cell specific targets is very desirable for cancer *** previous study firstly found that a secretory peroxidase of class III derived from foxtail millet bran(FMBP)exhibited excellent targeting anti-colorectal cancer(CRC)activity in vivo and in vitro,whereas its underlying target remains *** highlight of present study focuses on the finding that cell surface glucose-regulated protein 78(cs GRP78)abnormally located on CRC is positively correlated with the anti-CRC effects of FMBP,indicating it serves as a potential target of FMBP against ***,we demonstrated that the combination of FMBP with the nucleotide binding domain(NBD)of cs GRP78interfered with the downstream activation of signal transducer and activator of transcription 3(STAT3)in CRC cells,thus promoting the intracellular accumulation of reactive oxygen species(ROS)and cell grown *** phenomena were further confirmed in nude mice tumor ***,our study highlights cs GRP78 acts as an underlying target of FMBP against CRC,uncovering the clinical potential of FMBP as a targeted agent for CRC in the future.