A new strategy for the stereoselective synthesis of 2,3-dideoxy-3-fluoro-D-ribofuranose derivatives

作     者：GUO, ZW HUANG, BG XIAO, WJ HUI, YZ LANG, SA 

作者机构：CHINESE ACAD SCISHANGHAI INST ORGAN CHEMSHANGHAI 200032PEOPLES R CHINA AMER CYANAMID CODIV MED RESPEARL RIVERNY 10965 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：1995年第13卷第4期

页      面：363-367页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

主　　题：NEW METHOD STEREOSELECTIVE SYNTHESIS 2,3-DIDEOXY-3-SUBSTITUTED-D-RIBOFURANOSIDE 

摘      要：The important intermediate for syntheses of various anti-HIV nucleoside analogues, methyl 2,3-dideoxy-3-fluoro-6-O-(p-methylbenzoyl)-alpha-D-ribofuranoside, was synthesized starting from 2-deoxy-D-ribose in 5 steps With an overall yield of 24%. This strategy can be also used for synthesizing other analogues with various substitutions at 3-C position.