Highly Stereocontrolled Total Syntheses of Cedrane Sesquiterpenes via Cascade [5+2] Cycloaddition/Etherification

作     者：Yuhan Zhang Zhiyong Chi Xiangxin Li Zhixiang Xie Yuhan Zhang;Zhiyong Chi;Xiangxin Li;Zhixiang Xie

作者机构：State Key Laboratory of Applied Organic Chemistry&College of Chemistry and Chemical EngineeringLanzhou University222 Tianshui South RoadLanzhouGansu 730000China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2022年第40卷第2期

页      面：183-189页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Financial support from the National Natural Science Founda-tion of China(Nos.21971096,21772079,&21672088) the Natural Science Foundation of Gansu Province(No.18JR4RA003)is acknowledged 

主　　题：Terpenoids Asymmetric synthesis Dehydrogenation Cascade[5+2]cycloaddition/etherification Protecting group-free 

摘      要：Cedrane sesquiterpenes possess common tricyclo[5.***.1.0^(1,5)]undecane core *** varied oxa-five-membered ring decorating their core structure to form 8-oxa-tetracyclo[7.***.2.0^(1,5).0^(6,13)]tridecane framework,containing six consecutive chiral centers(including two all-carbon quaternary centers and one oxygenated quaternary carbon center),has proven to be a synthetic challenge and a biosynthetic mystery to date.