"Moonlighting" at the power plant: how mitochondria facilitate serial killing by CD8^(+) cytotoxic T cells

作     者：Dimitrios Mougiakakos Sascha Kahlfuss Dimitrios Mougiakakos;Sascha Kahlfuss

作者机构：Department of HematologyOncologyand Stem Cell TransplantationOtto-von-Guericke University MagdeburgMagdeburgGermany Institute of Molecular and Clinical ImmunologyMedical FacultyOtto-von-Guericke University MagdeburgMagdeburgGermany Institute of Medical Microbiology and Hospital HygieneMedical FacultyOtto-von-Guericke University MagdeburgMagdeburgGermany Health Campus ImmunologyInfectiologyInflammation(GC-I3)Medical FacultyOtto-von-Guericke UniversityMagdeburgGermany Center for Health and Medical Prevention(CHaMP)Otto-von-Guericke UniversityMagdeburgGermany 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2022年第7卷第1期

页      面：15-16页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：This work was supported by the Deutsche Forschungsgemeinschaft(DFG German Research Foundation)-361210922/GRK2408—(Project 12 RTG2408)to S.K.and—MOI 939/4-1 to D.M.Figure 1 was created in part with BioRender.com 

主　　题：cytotoxic immunity lighting 

摘      要：Griffiths and colleagues rece ntly dem on strated in Science^(1) that mitochondrial translation is required by CD8^(+)cytotoxic T cells(CTLs)to facilitate serial killing of target ***8^(+)CTLs provide immunity to viruses and tumors by acting as serial killers that eliminate infected or transformed target cells one after *** achieve that,CTLs utilize a cytotoxic protein machinery that involves perforin and granzymes to activate effector caspases and to induce apoptosis in target cells.