Metal-Free Synthesis of Benzo[a]phenanthridines from Aromatic Aldehydes,Cyclohexanones,and Aromatic Amines
作者机构：Key Laboratory for Green Organic Synthesis and Application of Hunan ProvinceKey Laboratory of Environmentally Friendly Chemistry and Application of Ministry of EducationCollege of ChemistryXiongtan UniversityXiangtanHunon 411105China Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates(South China University of Technology)GuangzhouGuangdong 510640China
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：2022年第40卷第3期
页 面：365-370页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：the National Natural Science Foundation of China(Nos.21871226 and 21572194) the Hunan Provincial Natural Science Foundation of China(2020JJ5531) the Open Fund of Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates,Guangzhou 510640,China(South China University of Technology)(No.2019B030301003) the Undergraduate Investigated Study and Innovated Experiment Plan from Ministry of Education of China and Hunan Province is gratefully acknowledged
主 题：Nitrogen heterocycles Multicomponent reactions Dehydroaromatization Cyclization Metal-free
摘 要：A three-component synthesis of benzo[a]phenanthridines from aromatic aldehydes,cyclohexanones,and aromatic amines has been developed,which is mediated by KI/DMSO/camphorsulfonic acid to afford a variety of functionalized benzo[a]phenanthridines in satisfactory *** present strategy provides a biaryl motif ortho to the nitrogen atom which has the potential to be used as ligand by further *** the advantages of readily available starting materials,transition-metal-free conditions,gram-scale synthesis,and broad substrate scope,this three-component protocol provides an efficient approach for the preparation of diverse benzo[a]phenanthridines.
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