Significance of differential allelic expression in phenotypic plasticity and evolutionary potential of microbial eukaryotes

作     者：Ben P.Tatman Thomas Mock Taoyang Wu Cock van Oosterhout Ben P.Tatman;Thomas Mock;Taoyang Wu;Cock van Oosterhout

作者机构：School of Environmental SciencesUniversity of East AngliaNorwich Research ParkNorwichNorfolkNR47TJUK Department of PhysicsUniversity of WarwickCoventryCV47ALUK School of Computer SciencesUniversity of East AngliaNorwich Research ParkNorwichNorfolkNR47TJUK 

出 版 物：《Quantitative Biology》 (定量生物学（英文版）)

年 卷 期：2021年第9卷第4期

页      面：400-410页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 08[工学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 

基　　金：Funding wasprovided by the NERC for the Research Experience Placement(REP)scheme awarded to the EnvEast doctoral training programme(EnvEast DTP)of the University of East Anglia(UEA).CvO was sponsored by the Earth&Life Systems Alliance(ELSA) 

主　　题：differential allelic expression daisyworld model adaptive evolution phenotypic plasticity 

摘      要：Background:Differential allelic expression(DAE)plays a key role in the regularion of many biological processes,and it may also play a role in adaptive ***,environment-dependent DAE has been observed in species of marine phytoplankton,and most remarkably,alleles that showed the highest level of DAE also showed the fastest rate of ***:To better understand the role of DAE in adaptive evolution and phenotypic plasticity,we developed a 2-D cellular automata model“DAEsy-Worldthat builds on the classical Daisyworld ***:Simulations show that DAE delineates the evolution of alternative alleles of a gene,enabling the two alleles to adapt to different environmental conditions and *** DAE,the build-up of genetic polymorphisms within genes is driven by positive selection rather than strict neutral evolution,and this can enhance phenotypic ***,in sexually reproducing organisms,DAE also increased the standing genetic variation,augmenting a species’adaptive evolutionary potential and ability to respond to fluctuating and/or changing conditions(cf,genetic assimilation).We furthermore show that DAE is likely to evolve in fluctuating environmental ***:DAE increases the adaptive evolutionary potential of both sexual and asexually reproducing organisms,and it may affect the pattern of nucleotide substitutions of genes.