The applications of catalytic asymmetric halocyclization in natural product synthesis
作者机构：Shaanxi Key Laboratory of Natural Products&Chemical BiologyCollege of Chemistry&PharmacyNorthwest A&F University22 Xinong RoadYangling 712100ShaanxiChina Key Laboratory of Botanical Pesticide R&D in Shaanxi ProvinceYanglingShaanxi 712100China
出 版 物：《Organic Chemistry Frontiers》 (有机化学前沿（英文）)
年 卷 期：2022年第9卷第2期
页 面：499-516页
核心收录：
学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 07[理学] 070303[理学-有机化学] 0703[理学-化学]
基 金：grateful for financial support from the National Natural Science Foundation of China(grants 21722206,21672171) Financial support from the Scientific Fund of Northwest A&F University is also acknowledged.
主 题：synthesis. cyclization asymmetric
摘 要：Halocyclization of olefinic substrate enables the establishment of cyclic skeletons via intramolecular halonium-induced nucleophilic addition,which has been well utilized as a practical strategy for constructing cyclic skeletons in natural product synthesis.Recently,the renaissance and rapid evolution of organocatalysis have accelerated the development of catalytic asymmetric halocyclization.In this context,natural product synthesis powered by catalytic asymmetric halocyclization has also achieved considerable progress in recent years.In some cases,these newly developed protocols enable more concise synthetic routes for accessing enantioenriched natural products.To this end,this review summarizes the applications of catalytic asymmetric halocyclization in natural product synthesis.
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