Recent advances in enhancing reactive oxygen species based chemodynamic therapy

作     者：Xinchao Li Rui Luo Xiuqi Liang Qinjie Wu Changyang Gong Xinchao Li;Rui Luo;Xiuqi Liang;Qinjie Wu;Changyang Gong

作者机构：State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2022年第33卷第5期

页      面：2213-2230页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.81822025) 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(No.ZYYC08002) 

主　　题：Chemdynamic therapy Fenton or fenton-like reactions Reactive oxygen species Increasing hydrogen peroxide levels Reducing glutathione levels External energy intervention Combination therapy 

摘      要：Chemodynamic therapy(CDT),defined as an in situ oxidative stress response catalyzed by the Fenton or Fenton-like reactions to generate cytotoxic hydroxyl radicals(•OH)at tumor sites,exhibits conspicuous inhibition of tumor *** has attracted extensive attention for its outstanding edge in effectiveness,lower systemic toxicity and side effects,sustainability,low cost and ***,the inconfor-mity of harsh Fenton reaction conditions and tumor microenvironment hamper its further development,based on which,numerous researchers have made efforts in further improving the efficiency of *** this review,we expounded antitumor capacity of CDT in mechanism,together with its limitation,and then summarized and came up with several strategies to enhance CDT involved tumor therapy strategies by 1)improving catalytic efficiency;2)increasing hydrogen peroxide levels at tumor sites;3)reducing glutathione levels at tumor sites;4)applying external energy intervention;5)amplifying the distribu-tion of hydroxyl radicals at tumor sites;and 6)combination ***,the perspectives and challenges of CDT are further discussed to encourage more in-depth studies and rational reflections.