Hypoxia adaptation in the cornea:Current animal models and underlying mechanisms

作     者：Kunpeng Pang Anton Lennikov Menglu Yang Kunpeng Pang;Anton Lennikov;Menglu Yang

作者机构：Harvard Medical School Department of OphthalmologySchepens Eye Research InstituteMassachusetts Eye and EarBostonMassachusettsUSA Department of OphthalmologyQilu Hospital of Shandong UniversityQingdaoChina 

出 版 物：《Animal Models and Experimental Medicine》 (动物模型与实验医学（英文）)

年 卷 期：2021年第4卷第4期

页      面：300-310页

核心收录：

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

主　　题：animal model contact lens wear cornea hypoxia hypoxia adaptation hypoxia inducible factor(HIF) 

摘      要：The cornea is an avascular,transparent tissue that is essential for visual *** disturbance to the corneal transparency will result in a severe vision *** to the avascular nature,the cornea acquires most of the oxygen supply directly or indirectly from the *** tissue hypoxia has been noticed to influence the structure and function of the cornea for *** etiology of hypoxia of the cornea is distinct from the rest of the body,mainly due to the separation of cornea from the atmosphere,such as prolonged contact lens wearing or closed *** hypoxia can also be found in corneal inflammation and injury when a higher oxygen requirement exceeds the oxygen *** hypoxic state during lung diseases or high altitude also leads to corneal hypoxia when a second oxygen consumption route from aqueous humor gets *** affects the cornea in multiple aspects,including disturbance of the epithelium barrier function,corneal edema due to endothelial dysfunction and metabolism changes in the stroma,and thinning of corneal *** has also evolved mechanisms to adapt to the hypoxic state initiated by the activation of hypoxia inducible factor(HIF).The aim of this review is to introduce the pathology of cornea under hypoxia and the mechanism of hypoxia adaptation,to discuss the current animal models used in this field,and future research directions.