RNA silencing:From discovery and elucidation to application and perspectives

作     者：Jian-Hua Zhao Hui-Shan Guo 

作者机构：State Key Laboratory of Plant GenomicsInstitute of Microbiologythe Chinese Academy of SciencesBeijing100101 China CAS Center for Excellence in Biotic InteractionsUniversity of the Chinese Academy of SciencesBeijing100049 China 

出 版 物：《Journal of Integrative Plant Biology》 (植物学报（英文版）)

年 卷 期：2022年第64卷第2期

页      面：476-498页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071007[理学-遗传学] 0901[农学-作物学] 0703[理学-化学] 0902[农学-园艺学] 

基　　金：supported by the National Natural Science Foundation of China(32020103003 31730078 and 32170293) 

主　　题：crop protection gene expression RNA silencing small RNAs trans-kingdom RNAi 

摘      要：RNA silencing(or RNA interference,RNAi)is a conserved mechanism for regulating gene expression in *** discovery of natural trans-kingdom RNAi indicated that small RNAs act as signaling molecules and enable communication between organisms in different *** phenomenon and potential mechanisms of trans-kingdom RNAi are among the most exciting research *** better understand trans-kingdom RNAi,we review the history of the discovery and elucidation of RNAi *** on canonical RNAi mechanisms,we summarize the major points of divergence around RNAi pathways in the main eukaryotes’kingdoms,including plants,animals,and *** review the representative incidents associated with the mechanisms and applications of trans-kingdom RNAi in crop protection,and discuss the critical factors that should be considered to develop successful trans-kingdom RNAi-based crop protection strategies.