Touchable cell biophysics property recognition platforms enable multifunctional blood smart health care
作者机构：Affiliations School of Physics&TechnologyKey Laboratory of Artificial Micro/Nano Structure of Ministry of EducationWuhan UniversityWuhan 430072China Shenzhen Research InstituteWuhan UniversityShenzhen 518000China Department of HematologyZhongnan HospitalWuhan UniversityWuhan 430071China Department of Laboratory MedicineZhongnan HospitalWuhan UniversityWuhan 430071China Remin Hospital of Wuhan UniversityWuhan UniversityWuhan 430060China School of MedicineZhejiang UniversityHangzhouZhejiang 310002China
出 版 物：《Microsystems & Nanoengineering》 (微系统与纳米工程（英文）)
年 卷 期：2021年第7卷第6期
页 面：207-219页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0804[工学-仪器科学与技术] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程]
基 金：This work was supported by the National Key R&D Program of China(2018YFC1003200) the National Natural Science Foundation of China(Nos.62175190,11774274,81860276,and 81770179) Foundation Research Fund of Shenzhen Science and Technology Program(No.JCYJ20190808154409678) Support Projects of Medical Science and Technology Innovation Platform of Wuhan University Zhongnan Hospital in 2020(lcyf202010)
摘 要：As a crucial biophysical property,red blood cell(RBC)deformability is pathologically altered in numerous disease states,and biochemical and structural changes occur over time in stored samples of otherwise normal ***,there is still a gap in applying it further to point-of-care blood devices due to the large external equipment(high-resolution microscope and microfluidic pump),associated operational difficulties,and professional ***,we revolutionarily propose a smart optofluidic system to provide a differential diagnosis for blood testing via precise cell biophysics property recognition both mechanically and *** of the RBC population is caused by pressing the hydrogel via an integrated mechanical transfer *** biophysical properties of the cell population are obtained by the designed smartphone *** intelligence-based modeling of cell biophysics properties related to blood diseases and quality was developed for online *** currently achieve 100%diagnostic accuracy for five typical clinical blood diseases(90 megaloblastic anemia,78 myelofibrosis,84 iron deficiency anemia,48 thrombotic thrombocytopenic purpura,and 48 thalassemias)via real-world prospective implementation;furthermore,personalized blood quality(for transfusion in cardiac surgery)monitoring is achieved with an accuracy of 96.9%.This work suggests a potential basis for next-generation blood smart health care devices.
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