Closed cranial window rodent model for investigating hemodynamic response to elevated intracranial pressure

作     者：Matt T.Oberdier James F.Antaki Alexander Kharlamov Stephen C.Jones Matt T.Oberdier;James F.Antaki;Alexander Kharlamov;Stephen C.Jones

作者机构：Department of Biomedical EngineeringCarnegie Mellon UniversityPittsburghPennsylvaniaUSA Department of AnesthesiologyAllegheny-Singer Research InstitutePittsburghPennsylvaniaUSA 

出 版 物：《Animal Models and Experimental Medicine》 (动物模型与实验医学（英文）)

年 卷 期：2021年第4卷第4期

页      面：391-397页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：This work was supported by a grant from the National Institute of General Medical Sciences(F31GM089135)to MTO 

主　　题：cerebrovascular circulation craniotomy hemodynamics hydrocephalus intracranial pressure perfusion 

摘      要：Background:Elevated intracranial pressure(ICP)occurs in several physiological and pathological conditions,yet long-term sequellae are not common,which implies that blood flow is preserved above ischemic ***:This pilot study sought to confirm this hypothesis using a closed cranial window model in a rat in which ICP was elevated to 120 mmHg for 12 min,and superficial cortical perfusion was measured by laser Doppler flowmetry and laser speckle ***:Following a transient increase,cortical blood flow decreased to between 25%and 75%of *** levels correspond to disrupted metabolism and decreased protein synthesis but did not exceed thresholds for electrical signaling or membrane *** may partially explain how some episodes of elevated ICP remain ***:The closed cranial window model provides a platform for prospective study of physiologic responses to artificially elevated ICP during neurosurgery to promote hemostasis.