Enteric nervous system and inflammatory bowel diseases:Correlated impacts and therapeutic approaches through the P2X7 receptor
作者机构：Department of SurgerySchool of Veterinary Medicine and Animal SciencesUniversity of São PauloSão Paulo 08000-000Brazil Department of AnatomyInstitute of Biomedical SciencesUniversity of São PauloSão Paulo 08000-000Brazil
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2021年第27卷第46期
页 面：7909-7924页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Supported by the Sao Paulo Research (FAPESP, Brazil),No. 2014/25927-2 and No. 2018/07862-1 the National Council for Scientific and Technological Development (CNPq, Brazil)
主 题：Chemical coding Enteric nervous system Gastroenterology Inflammatory bowel diseases P2X7 receptor Purinergic signaling
摘 要：The enteric nervous system(ENS)consists of thousands of small ganglia arranged in the submucosal and myenteric plexuses,which can be negatively affected by Crohn’s disease and ulcerative colitis-inflammatory bowel diseases(IBDs).IBDs are complex and multifactorial disorders characterized by chronic and recurrent inflammation of the intestine,and the symptoms of IBDs may include abdominal pain,diarrhea,rectal bleeding,and weight *** P2X7 receptor has become a promising therapeutic target for IBDs,especially owing to its wide expression and,in the case of other purinergic receptors,in both human and model animal enteric ***,little is known about the actual involvement between the activation of the P2X7 receptor and the cascade of subsequent events and how all these activities associated with chemical signals interfere with the functionality of the affected or treated *** this review,an integrated view is provided,correlating the structural organization of the ENS and the effects of IBDs,focusing on cellular constituents and how therapeutic approaches through the P2X7 receptor can assist in both protection from damage and tissue preservation.
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