Feasibility of Booster Vaccination in High-Risk Populations for Controlling Coronavirus Variants—China,2021

作     者：Kangguo Li Zeyu Zhao Hongjie Wei Jia Rui Jiefeng Huang Xiaohao Guo Yichao Guo Shiting Yang Guzainuer Abudurusuli Li Luo Xingchun Liu Yao Wang Jingwen Xu Yuanzhao Zhu Meng Yang TianlongYang Weikang Liu Bin Deng Chan Liu Zhuoyang Li Peihua Li Shanshan Yu Zimei Yang Yanhua Su Benhua Zhao Yan Niu Tianmu Chen 

作者机构：State Key Laboratory of Molecular Vaccinology and Molecular DiagnosticsSchool of Public HealthXiamen UniversityXiamenFujianChina Universitéde MontpellierMontpellierFranceCIRADIntertrypMontpellierFranceIESUniversitéde Montpellier-CNRSMontpellierFrance Chinese Center for Disease Control and PreventionBeijingChina. 

出 版 物：《China CDC weekly》 (中国疾病预防控制中心周报（英文）)

年 卷 期：2021年第3卷第50期

页      面：1071-1074,I0001-I0004页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：Bill&Melinda Gates Foundation(INV-005834) 

主　　题：vaccine acute respiratory 

摘      要：Introduction:Vaccination booster shots are completely necessary for controlling breakthrough infections of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in *** study aims to estimate effectiveness of booster vaccines for high-risk populations(HRPs).Methods:A vaccinated Susceptible-Exposed-Symptomatic-Asymptomatic-Recovered/Removed(SEIAR)model was developed to simulate scenarios of effective reproduction number(Reff)from 4 to *** number of infectious and asymptomatic cases were used to evaluated vaccination ***:Our model showed that we could not prevent outbreaks when covering 80%of HRPs with booster unless Reff=4.0 or the booster vaccine had efficacy against infectivity and susceptibility of more than 90%.The results were consistent when the outcome index was confirmed cases or asymptomatic ***:An ideal coronavirus disease 2019(COVID-19)booster vaccination strategy for HRPs would be expected to reach the initial goal to control the transmission of the Delta variant in ***,the recommendation for the COVID-19 booster vaccine should be implemented in HRPs who are already vaccinated and could prevent transmission to other groups.