Consensus molecular subtypes of colorectal cancer in clinical practice:A translational approach
作者机构：Basic and Clinical Oncology DepartmentUniversity of ChileSantiago 8380453Chile
出 版 物：《World Journal of Clinical Oncology》 (世界临床肿瘤学杂志（英文版）)
年 卷 期：2021年第12卷第11期
页 面：1000-1008页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Agencia Nacional de Investigación y Desarrollo de Chile Fondo Nacional de Investigación y Desarrollo en Salud FONIS No.SA20I0059
主 题：Colorectal neoplasms Precision medicine Microsatellite instability Nextgeneration sequencing
摘 要：The identification of several genetic mutations in colorectal cancer(CRC)has allowed a better comprehension of the prognosis and response to different antineoplastic ***,through a systematic process,consensus molecular subtypes(CMS)have been described to characterize genetic and molecular mutations in CRC *** CMS,CRC patients can be categorized into four molecular subtypes of CRC by wide transcriptional genome ***1 has microsatellite instability and mutations in CIMP and BRAF ***2,distinguished by mutations in specific pathways linked to cellular metabolism,also has a better ***3 has a KRAS mutation as a ***4 presents mutations in fibrogenesis pathways and mesenchymalepithelial transition,associated with a worse *** classification can be a meaningful step in providing possible answers to important issues in CRC,such as the use of adjuvant chemotherapy in stage II,personalized first-line chemotherapy for metastasic CRC,and possible new target treatments that address specific pathways in each molecular *** CMS is a crucial step in personalized medicine,although prospective clinical trials selecting patients by CMS are required to pass proof-of-concept before becoming a routine clinical tool in oncology routine care.
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