Tumor characteristics of hepatocellular carcinoma after direct-acting antiviral treatment for hepatitis C: Comparative analysis with antiviral therapy-naive patients

作     者：Magdy Fouad Mohamed El Kassas Elham Ahmed Reem El Sheemy 

作者机构：Department of Tropical Medicine and GastroenterologyMinia UniversityMinia 61519Egypt Department of Endemic MedicineFaculty of MedicineHelwan UniversityCairo 11795Egypt Department of Internal MedicineMinia UniversityMinia 61519Egypt Department of Tropical MedicineMinia UniversityMinia 61111Egypt 

出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)

年 卷 期：2021年第13卷第11期

页      面：1743-1752页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：Minia University 

主　　题：Hepatocellular carcinoma Direct-acting antiviral treatment Hepatitis C Tumor behavior Occurrence 

摘      要：BACKGROUND Insufficient and contradictory data are available about the relation between directacting antivirals(DAAs)and hepatocellular carcinoma(HCC)development in patients with hepatitis C virus(HCV).AIM To analyze differences in basic clinical,radiological,and laboratory characteristics in addition to tumor behavior upon HCC diagnosis between patients with and without a previous history of DAAs *** This multicenter case-control study included 497 patients with chronic HCVrelated HCC,allocated into one of two groups according to their history of antiviral treatment for their *** Group I included 151 HCC patients with a history of DAAs,while 346 patients who had never been treated with DAAs were assigned to group II.A significant difference was observed between both groups regarding basic assessment scores(Child,MELD,and BCLC),which tended to have more advanced liver disease and HCC stage upon diagnosis in group ***,serum albumin was significantly affected,and serumα-fetoprotein was significantly higher in group II(P0.001).In addition,group I showed significant HCC multicentricity than group II,while the incidence of portal vein thrombosis was significantly higher in group I(P0.001).CONCLUSION The basic clinical scores and laboratory characteristics of HCC patients are advanced in patients who are naïve to DAAs treatment;however,HCC behavior is more aggressive in DAA-treated patients.