Rational design and synthesis of upconversion luminescence-based optomagnetic multifunctional nanorattles for drug delivery

作     者：Xuhua Liang Yanyan Zhao Min Cheng Fei Zhang Xuhua Liang;Yanyan Zhao;Min Cheng;Fei Zhang

作者机构：College of Biology Pharmacy and Food EngineeringShangluo UniversityShangluo 726000China Shaanxi Qinling Industrial Technology Research Institute of Special Biological ResourcesShangluo 726000China Shaanxi Tasly Plants Pharmaceutical Co.LtdShangluo 726000China 

出 版 物：《Chinese Journal of Chemical Engineering》 (中国化学工程学报（英文版）)

年 卷 期：2021年第34卷第10期

页      面：286-293页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 07[理学] 070205[理学-凝聚态物理] 0817[工学-化学工程与技术] 0703[理学-化学] 0702[理学-物理学] 10[医学] 

基　　金：supported by the Key Research and Development Plan of Shaanxi Province(2020GY-313) the Specialized Research Fund of Education Department of Shaanxi Province(19JK0255) the Specialized Scientific Research Fund Projects of Academician Shengyong Zhang(18YSZX001) the Science and Technology Innovation Team of Shangluo University(20SCX02)。 

主　　题：Optomagnetic nanocomposite Nanorattle Upconversion luminescence Iron oxide Drug delivery 

摘      要：Optomagnetic multifunctional composite based on upconversion luminescence nanomaterial is regarded as a promising strategy for bioimaging,disease diagnosis and targeted delivery of drugs.To explore a mesoporous nanostructure with excellent water dispersibility and high drug-loading capacity,a novel nanorattle-structured Fe3O4@SiO2@NaYF4:Yb,Er magnetic upconversion nanorattle(MUCNR)was successfully designed by using Fe3O4 as core and NaYF4:Yb,Er nanocrystals as shell.The microstructures and crystal phase of the as-prepared MUCNRs were evaluated by transmission electron microscopy,Xray powder diffraction and N2 adsorption/desorption isotherms.The Kirkendall effect was adapted to explain the formation mechanism of the MUCNRs.The loading content and encapsulation efficiency of doxorubicin hydrochloride(DOX)could reach as high as 18.2%and 60.7%,respectively.Moreover,the DOX loading MUCNR(DOX-MUCNR)system showed excellent sustained drug release and strong p Hdependent performance,which was conducive to drug release at the slightly acidic microenvironment of tumor.Microcalorimetry was used to quantify the interactions between the carrier structure and drug release rate directly.The heat release rates in the heat-flow diagrams are basically consistent with the DOX release rate,thereby showing that microcalorimetry assay not only provides a unique thermodynamic explanation for the structure–activity relationship of Fe3O4@SiO2@NaYF4:Yb,Er MUCNRs but also provides powerful guidance to avoid the blind selection or design of drug carriers.Therefore,our work firmly provided a comprehensive perspective for using Fe3O4@SiO2@NaYF4:Yb,Er MUCNRs as a remarkable magnetic targeted drug carrier.