Natural exosome-like nanovesicles from edible tea flowers suppress metastatic breast cancer via ROS generation and microbiota modulation

作     者：Qiubing Chen Qian Li Yuqi Liang Menghang Zu Nanxi Chen Brandon S.B.Canup Liyong Luo Chenhui Wang Liang Zeng Bo Xiao Qiubing Chen;Qian Li;Yuqi Liang;Menghang Zu;Nanxi Chen;Brandon S.B.Canup;Liyong Luo;Chenhui Wang;Liang Zeng;Bo Xiao

作者机构：State Key Laboratory of Silkworm Genome BiologyCollege of SericultureTextileand Biomass SciencesSouthwest UniversityChongqing 400715China Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function ManufacturingSchool of Materials and EnergySouthwest UniversityChongqing 400715China Department of ChemistryCenter for Diagnostics and TherapeuticsGeorgia State UniversityAtlantaGA 30303USA College of Food ScienceSouthwest UniversityChongqing 400715China Chongqing Key Laboratory of Natural Product Synthesis and Drug ResearchSchool of Pharmaceutical SciencesChongqing UniversityChongqing 401331China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2022年第12卷第2期

页      面：907-923页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(82072060 and 81571807,China) the Fundamental Research Funds for the Central Universities(XDJK2019TY002 and 2020CDJQY-A041,China) the Natural Science Foundation Project of Chongqing(cstc2020jcyjmsxm X0292,China) the Venture&Innovation Support Program for Chongqing Overseas Returnees(cx2018029,China) 

主　　题：Tea flower Exosome-like nanoparticle Breast cancer Metastasis ROS generation Microbiota modulation Intravenous injection Oral administration 

摘      要：Although several artificial nanotherapeutics have been approved for practical treatment of metastatic breast cancer,their inefficient therapeutic outcomes,serious adverse effects,and high cost of mass production remain crucial ***,we developed an alternative strategy to specifically trigger apoptosis of breast tumors and inhibit their lung metastasis by using natural nanovehicles from tea flowers(TFENs).These nanovehicles had desirable particle sizes(131 nm),exosome-like morphology,and negative zeta ***,TFENs were found to contain large amounts of polyphenols,flavonoids,functional proteins,and *** experiments revealed that TFENs showed strong cytotoxicities against cancer cells due to the stimulation of reactive oxygen species(ROS)*** increased intracellular ROS amounts could not only trigger mitochondrial damage,but also arrest cell cycle,resulting in the in vitro anti-proliferation,anti-migration,and anti-invasion activities against breast cancer *** mice investigations demonstrated that TFENs after intravenous(i.v.)injection or oral administration could accumulate in breast tumors and lung metastatic sites,inhibit the growth and metastasis of breast cancer,and modulate gut *** study brings new insights to the green production of natural exosome-like nanoplatform for the inhibition of breast cancer and its lung metastasis via *** oral routes.