A novel model of molnupiravir against SARS-CoV-2 replication: accumulated RNA mutations to induce error catastrophe

作     者：Yuxi Zhao Gu He Wei Huang Yuxi Zhao;Gu He;Wei Huang

作者机构：West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan University and Collaborative Innovation Center of BiotherapyChengduChina State Key Laboratory of Southwestern Chinese Medicine ResourcesHospital of Chengdu University of Traditional Chinese MedicineSchool of PharmacyChengdu University of Traditional Chinese MedicineChengduChina 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2022年第7卷第1期

页      面：1-3页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

基　　金：This work was supported by the grants from the NSFC(Nos.81773890,21772131,82073997) the Fundamental Research Funds of Science&Technology Department of Sichuan Province(No.2021YFS0044) Project First-Class Disciplines Development supported by CDUTCM 

主　　题：prevention al. catastrophe 

摘      要：RNA-dependent RNA polymerase(RdRp),also known as nsp12,is a key comp on ent in the syn thesis of viral ribonucleic acid(RNA)and is considered the primary target of nucleoside analog(NA)inhibitors.A recent publication by Kabinger et *** the unique molecular mechanisms of molnupiravir on inducing RNA mutations by RdRp during replication of SARS-CoV-2.^(1) As an oral broad-spectrum NA an tiviral age nt,moln upiravir has bee n prove n with considerable potential for the prevention and treatment of Corona Virus Disease 2019(COVID-19)(Fig.1).^(2)