Instructive cartilage regeneration modalities with advanced therapeutic implantations under abnormal conditions

作     者：Zhonghan Wang Hanxiang Le Yanbing Wang He Liu Zuhao Li Xiaoyu Yang Chenyu Wang Jianxun Ding Xuesi Chen 

作者机构：Department of Plastic and Reconstruct SurgeryThe First Hospital of Jilin University1 Xinmin StreetChangchun130021PR China Department of OrthopedicsThe Second Hospital of Jilin University218 Ziqiang StreetChangchun130041PR China Key Laboratory of Polymer EcomaterialsChangchun Institute of Applied ChemistryChinese Academy of Sciences5625 Renmin StreetChangchun130022PR China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2022年第7卷第5期

页      面：317-338页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 1010[医学-医学技术（可授医学、理学学位）] 0805[工学-材料科学与工程（可授工学、理学学位）] 100215[医学-康复医学与理疗学] 10[医学] 

基　　金：financially supported by the National Natural Science Foundation of China(Grant Nos.82102358,82001971,81701811,and 81772456) the Science and Technology Development Program of Jilin Province(Grant Nos.20200802008GH,20200404202YY,20200404190YY,20200404140YY,20200403088SF,20190304123YY,20190201068JC,20180623050TC,and 20180201041SF) the Health Department Program of Jilin Province(Grant Nos.2020Q018,2019SCZT001,2019SCZT014,2019SRCJ001,and 2017F007) the Youth Talents Promotion Project of Jilin Province(Grant No.192004) the Interdisciplinary Research Funding Program for Doctoral Candidates of Jilin University(Grant No.41900200861) 

主　　题：Cartilage lesion Pathological microenvironment Synergistic effect Tissue engineering Cartilage regeneration 

摘      要：The development of interdisciplinary biomedical engineering brings significant breakthroughs to the field of cartilage ***,cartilage defects are considerably more complicated in clinical conditions,especially when injuries occur at specific sites(e.g.,osteochondral tissue,growth plate,and weight-bearing area)or under inflammatory microenvironments(e.g.,osteoarthritis and rheumatoid arthritis).Therapeutic implantations,including advanced scaffolds,developed growth factors,and various cells alone or in combination currently used to treat cartilage lesions,address cartilage regeneration under abnormal *** review summarizes the strategies for cartilage regeneration at particular sites and pathological microenvironment regulation and discusses the challenges and opportunities for clinical transformation.