Evaluation of antibiotic resistance patterns in clinical isolates of Klebsiella pneumoniae in Bangladesh

作     者：Parama Aminul Shaheda Anwar Md.Maruf Ahmed Molla Md.Ruhul Amin Miah 

作者机构：Department of MicrobiologyAMCJJashoreBangladesh Department of Microbiology and ImmunologyBSMMUShahbagDhakaBangladesh Department of VirologyNational Institute of Laboratory Medicine and Referral CenterDhakaBangladesh 

出 版 物：《Biosafety and Health》 (生物安全与健康（英文）)

年 卷 期：2021年第3卷第6期

页      面：301-306页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1010[医学-医学技术（可授医学、理学学位）] 10[医学] 

基　　金：supported by the Department of Microbiology and Immunology BSMMU and the Research fund of Bangabandhu Sheikh Mujib Medical University(BSMMU) 

主　　题：MDR Klebsiella pneumoniae ESBL Antibiotic resistance Bangladesh 

摘      要：The treatment of *** infections has become more difficult due to the emergence of multidrugresistant *** study aimed to evaluate antimicrobial resistance patterns and detect different types of beta-lactamase genes among MDR and non-MDR Klebsiella pneumoniae in various clinical samples.A total of 150 Klebsiella pneumoniae were identified from different clinical samples by conventional microbiological *** sensitivity was detected by the Kirby-Bauer disc diffusion ***-spectrum betalactamase,Metallo-β-lactamase,and carbapenemase were phenotypically detected by double-disk synergy test,combined disk assay,and modified Hodge *** also detected differentβlactamase genes and virulence *** majority of Klebsiella pneumoniae were multi-drug resistant(82%).The bacteria were found resistant to mostβ-lactam antibiotics,aminoglycosides,ciprofloxacin,cotrimoxazole,carbapenem,piperacillin,and ***,only about 0.7%colistin resistance was observed.A double-disk synergy test was performed among the isolates for phenotypic detection of ESBL producing Klebsiella *** 16.6%of isolates were found to be ESBL ***β-lactamase genes,NDM(23.34%),OXA-48(8%),and KPC(7.3%)were *** prevalentβlactamase genes VIM and IMP were not *** summary,the prevalence of MDR Klebsiella pneumoniae is high in Bangladesh,which may complicate the treatment of hospitalized patients.