FNDC4 and FNDC5 reduce SARS-CoV-2 entry points and spike glycoprotein S1-induced pyroptosis, apoptosis, and necroptosis in human adipocytes
作者机构：Metabolic Research LaboratoryClínica Universidad de NavarraPamplonaSpain CIBER Fisiopatología de la Obesidad y Nutrición(CIBEROBN)Instituto de Salud Carlos IIIMadridSpain Obesity and Adipobiology GroupInstituto de Investigación Sanitaria de Navarra(IdiSNA)PamplonaSpain Department of Endocrinology and NutritionClínica Universidad de NavarraPamplonaSpain Department of SurgeryClínica Universidad de NavarraPamplonaSpain Department of AnesthesiaClínica Universidad de NavarraPamplonaSpain Department of Biomedical Sciences and Human OncologyClinica Medica“A.Murri”University of Bari Medical SchoolPoliclinico HospitalBariItaly.
出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)
年 卷 期：2021年第18卷第10期
页 面：2457-2459页
核心收录：
学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学]
基 金：This work was supported by Fondo de Investigación Sanitaria-FEDER(FIS PI19/00785 and PI19/00990) the Instituto de Salud Carlos III and the Department of Health of the Gobierno de Navarra(exp.0011-3638-2020-000002).
摘 要：A sedentary lifestyle and obesity are important risk factors for severe COVID-19 complications and death[1,2].Excessive adipose tissue(AT)might contribute to more extensive viral spread with increased shedding,immune activation,and cytokine amplification[3].Several factors secreted by contracting muscle,termed myokines,mediate the beneficial effects of exercise in a wide range of diseases,including obesity[4].Thus,we conducted a study to explore the potential role of myokines of the fibronectin type III domain-containing family,FNDC4 and FNDC5,in mechanisms underlying the increased susceptibility to COVID-19 complications in obesity.
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