Natural killer cell-derived exosomal miR-1249-3p attenuates insulin resistance and inflammation in mouse models of type 2 diabetes

作     者：Ying Wang Mengwei Li Lin Chen Huan Bian Xiangying Chen Huilin Zheng Peiwei Yang Quan Chen Hanmei Xu Ying Wang;Mengwei Li;Lin Chen;Huan Bian;Xiangying Chen;Huilin Zheng;Peiwei Yang;Quan Chen;Hanmei Xu

作者机构：The Engineering Research Center of Synthetic Peptide Drug Discovery and Evaluation of Jiangsu ProvinceChina Pharmaceutical University210009 NanjingChina State Key Laboratory of Natural MedicinesMinistry of EducationChina Pharmaceutical University210009 NanjingChina 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2021年第6卷第12期

页      面：3783-3795页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This work was supported by grants from the Project Program of State Key Laboratory of Natural Medicines(SKLNMZZCX201821,SKLNMZZ202028) the National Science and Technology Major Projects of New Drugs(2019ZX09301124,2019ZX09201001,and 2019ZX09301-110)in China This work was also supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD) China Postdoctoral Science Foundation(2017M621884,2020M681787) “Double First-Class”University project of China Pharmaceutical University(CPU2018GY13,CPU2018PZH03) 

主　　题：inflammation miR124 killer 

摘      要：Natural killer(NK)cells have been suggested to be associated with type 2 diabetes by regulating systemic ***,the mechanism by which NK cells regulate insulin sensitivity remains *** study shows that NK-derived exosomes from lean mice attenuate obesity-induced insulin resistance and inflammation in mice of type 2 ***,lean NK-derived exosomes enhance insulin sensitivity and relieve inflammation in adipocytes and ***-1249-3p,which is significantly upregulated in lean NK-derived exosomes,can be transferred from NK cells to adipocytes and hepatocytes via *** exosomal miR-1249-3p dramatically induces cellular insulin sensitivity and relieves ***,exosomal miR-1249-3p directly targets SKOR1 to regulate the formation of ternary complex SMAD6/MYD88/SMURF1,which mediates glucose homeostasis by suppressing the TLR4/NF-κB signaling *** study reveals an emerging role for NK-derived exosomal miR1249-3p in remission of insulin resistance,and provides a series of potential therapeutic targets in type 2 diabetes.