Lithium chloride promotes osteogenesis and suppresses apoptosis during orthodontic tooth movement in osteoporotic model via regulating autophagy

作     者：Li Huang Xing Yin Jun Chen Ruojing Liu Xiaoyue Xiao Zhiai Hu Yan He Shujuan Zou 

作者机构：State Key Laboratory of Oral DiseasesNational Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu610041China The Medical&Nursing SchoolChengdu UniversityChengdu610106China Laboratory for Regenerative MedicineTianyou HospitalWuhan University of Science and TechnologyWuhan430064China Department of Oral and Maxillofacial SurgeryMassachusetts General Hospital and Harvard School of Dental MedicineBostonMA02114USA 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2021年第6卷第10期

页      面：3074-3084页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程] 10[医学] 

基　　金：This work was supported by National Natural Science Foundation of China(Grants No.81801019,81701032,82071150) National Key Research and Development Program of China(Grant No.2018YFC1105703). 

主　　题：Lithium chloride Autophagy Osteogenesis Orthodontic tooth movement Apoptosis 

摘      要：Osteoporosis is a widely distributed disease that may cause complications such as accelerated tooth movement,bone resorption,and tooth loss during orthodontic treatment.Promoting bone formation and reducing bone resorption are strategies for controlling these complications.For several decades,the autophagy inducer lithium chloride(LiCl)has been explored for bipolar.In this study,we investigated the autophagy-promoting effect of LiCl on bone remodeling under osteoporotic conditions during tooth movement.Ovariectomy was used to induce osteoporosis status in vivo.The results showed that LiCl rejuvenated autophagy,decreased apoptosis,and promoted bone formation,thus protecting tooth movement in osteoporotic mice.Furthermore,in vitro experiments showed that LiCl reversed the effects of ovariectomy on bone marrow-derived mesenchymal stem cells(BMSCs)extracted from ovariectomized mice,promoting osteogenesis and suppressing apoptosis by positively regulating autophagy.These findings suggest that LiCl can significantly decrease adverse effects of osteoporosis on bone remodeling,and that it has great potential significance in the field of bone formation during tooth movement in osteoporosis patients.