Rhodium(Ⅲ)-catalyzed [4+2] annulation of N-arylbenzamidines with1,4,2-dioxazol-5-ones: Easy access to 4-aminoquinazolines via highly selective C-H bond activation

作     者：Jie Ren Yanzhen Huang Chao Pi Xiuling Cui Yangjie Wu Jie Ren;Yanzhen Huang;Chao Pi;Xiuling Cui;Yangjie Wu

作者机构：Henan Key Laboratory of Chemical Biology and Organic ChemistryKey Laboratory of Applied Chemistry of Henan UniversitiesGreen Catalysis Center and College of ChemistryZhengzhou UniversityZhengzhou 450052China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2021年第32卷第8期

页      面：2592-2596页

核心收录：

学科分类：07[理学] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：financial support from the Ministry of Science and Technology of China (No.2016YFE0132600) Henan Center for Outstanding Overseas Scientists (No.GZS2020001) Zhengzhou University。 

主　　题：[4+2]Annulation N-Arylbenzamidine 4-Aminoquinazoline Excellent regioselectivity High step economy 

摘      要：A novel approach for the synthesis of 4-aminoquinazolines has been developed via rhodium(Ⅲ)-catalyzed [4+2] annulation of N-arylbenzamidines with 1,4,2-dioxazol-5-ones.This reaction features excellent regioselectivity,broad substrate scope and high step economy,which would provide the refe rence for the construction of the fused 4-aminoquinazolines with biologically and pharmacologically active compounds.