Long-term effects of metformin use in gestational diabetes mellitus on offspring health

作     者：Ayan Roy Jayaprakash Sahoo 

作者机构：Department of Endocrinology and MetabolismAll India Institute of Medical SciencesJodhpur 342005RajasthanIndia Department of EndocrinologyJawaharlal Institute of Postgraduate Medical Education and ResearchPuducherry 605006India 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)

年 卷 期：2021年第12卷第11期

页      面：1812-1817页

核心收录：

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

主　　题：Anthropometry Fetal Gestational diabetes mellitus Long-term Metformin Offspring 

摘      要：Metformin is the first-line drug for the treatment of type 2 diabetes mellitus,but its role in gestational diabetes mellitus(GDM)management is not *** evidence suggests a certain beneficial effect of metformin in the treatment of GDM,but a high treatment failure rate leads to the initiation of additional medications,such as ***,since metformin crosses the placental barrier and reaches a significant level in the fetus,it is likely to influence the fetal metabolic *** evidence indicates the long-term safety in children exposed to metformin in utero except for mild adverse anthropometric *** follow-up of metformin-exposed offspring is warranted from the clinician’s point of view.