Addition of castor oil as a booster in colon capsule regimens significantly improves completion rates and polyp detection

作     者：Serhiy Semenov Mohd Syafiq Ismail Fintan O'Hara Sandeep Sihag Barbara Ryan Anthony O'Connor Sarah O'Donnell Deirdre McNamara 

作者机构：Gastroenterology DepartmentTallaght University HospitalDublin D 24Ireland Trinity Academic Gastroenterology GroupTrinity College DublinDublin D 2Ireland 

出 版 物：《World Journal of Gastrointestinal Pharmacology and Therapeutics》 (世界胃肠药理与治疗学杂志（英文版）（电子版）)

年 卷 期：2021年第12卷第6期

页      面：103-112页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Castor oil Colon capsule endoscopy Bowel preparation Completion rates Excretion rates 

摘      要：BACKGROUND Incomplete excretion rates are problematic for colon capsule endoscopy(CCE).Widely available booster regimens are *** published data on one day preparation CCE protocol using castor oil appeared *** To assess the impact of adding castor oil to a standard split-dose(2-d)preparation in an unselected Western patient *** All patients aged 18 or more referred to our unit for a CCE over a 5-mo period were prospectively *** were retrospectively identified from our CCE *** patients received split bowel preparation with Moviprep■[polyethylene glycol(PEG)-3350,sodium sulphate,sodium chloride,potassium chloride,sodium ascorbate and ascorbic acid for oral solution;Norgine B.V,United States],a PEG-based solution used predominantly in our colonoscopy *** booster regimen included Moviprep■with 750 mL of water(booster 1)on reaching the small bowel.A further dose of Moviprep■with 250 mL of water was given 3 h later and a bisacodyl suppository(Dulcolax■)10 mg after 8 h,if the capsule was not *** addition to our standard booster regimen,cases received an additional 15 mL of castor oil given at the time of booster 1.A nested case control design with 2:1 ratio(control:case)was *** demographics,completion rates,image quality,colonic transit time,diagnostic yield and polyp detection were compared between groups,using a student t or chi-square tests as *** One hundred and eighty-six CCEs[mean age 60 years(18-97),56%females,n=104],including 62 cases have been *** breakdown included 96 polyp surveillance(51.6%),42 lower gastrointestinal symptoms(22.6%),28 due to incomplete colonoscopy(15%),18 anaemia(9.7%)and 2 inflammatory bowel disease surveillance(1.1%).Overall,CCE completion was 77%(144/186),image quality was adequate/diagnostic in 91%(170/186),mean colonic transit time was 3.5 h(0.25-13),and the polyp detection rate was 57%(106/186).Completion rates wer