Pharmaconutrition strategy to resolve SARS-CoV-2-induced inflammatory cytokine storm in non-alcoholic fatty liver disease:Omega-3 long-chain polyunsaturated fatty acids
作者机构：Department of Clinical PharmacologyICMR-National Institute for Research in TuberculosisChennai 600031Tamil NaduIndia Department of BiochemistryNational Institute of NutritionHyderabad 500007TelanganaIndia
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2021年第9卷第31期
页 面：9333-9349页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Lipids Virus Inflammation Infection Fish oil Supplementation
摘 要：Inflammation is one of the primary factors associated with the causation and/or progression of several lifestyle disorders,including obesity,type 2 diabetes and non-alcoholic fatty liver disease(NAFLD).NAFLD is a spectrum of disorders,and starts with simple steatosis,progresses to non-alcoholic steatohepatitis,and then advances to fibrosis,cirrhosis and finally,hepatocellular carcinoma,due to perpetual cycles of insults caused by inflammation and other cellular *** evidence has documented that patients with NAFLD have severe coronavirus disease 2019(COVID-19),and patients with COVID-19 have a higher liver injury and *** the exact cause or mechanism is not known,inflammatory cytokine storm is a characteristic feature of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection and is known to be associated with higher mortality among COVID-19 ***,the COVID-19 pandemic seems to be a major concern in NAFLD patients,who have contracted SARS-CoV-2 infection and develop *** is evident in patients at any stage of the NAFLD spectrum,as the inflammatory cytokine storm may cause and/or aggravate the progression or severity of ***,there is a need for resolution of the inflammatory cytokine storm in these patients.A large body of evidence has demonstrated the efficacy of omega-3 long-chain polyunsaturated fatty acids(ω-3 LCPUFA)in NAFLD conditions,due to their anti-inflammatory,immunomodulatory and anti-viral ***,intervention withω-3 LCPUFA,an effective pharmaconutrient along with the standard treatment for COVID-19 may be useful in the management of the NAFLD spectrum in COVID-19 patients with pre-existing NAFLD conditions by resolving the inflammatory cytokine storm and thereby attenuating its *** there are challenges in implementation,optimistically they can be circumvented and the pharmaconutrition strategy may be potentially helpful in tackling both the pandemics;NAFLD a
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