Infection with severe fever with thrombocytopenia virus in healthy population:a cohort study in a high endemic region,China

作     者：Xiao‑Lei Ye Ke Dai Qing‑Bin Lu Yan‑Qin Huang Shou‑Ming Lv Pan‑He Zhang Jia‑Chen Li Hai‑Yang Zhang Zhen‑Dong Yang Ning Cui Chun Yuan Kun Liu Xiao‑Ai Zhang Jiu‑Song Zhang Hao Li Yang Yang Li‑Qun Fang Wei Liu Xiao-Lei Ye;Ke Dai;Qing-Bin Lu;Yan-Qin Huang;Shou-Ming Lv;Pan-He Zhang;Jia-Chen Li;Hai-Yang Zhang;Zhen-Dong Yang;Ning Cui;Chun Yuan;Kun Liu;Xiao-Ai Zhang;Jiu-Song Zhang;Hao Li;Yang Yang;Li-Qun Fang;Wei Liu

作者机构：State Key Laboratory of Pathogen and BiosecurityBeijing Institute of Micro‑biology and Epidemiology20 Dong‑Da StreetFengtai DistrictBeijing 100071People’s Republic of China Department of Laboratorial Science and Tech‑nologySchool of Public HealthPeking UniversityBeijing 100191People’s Republic of China Shangcheng Center for Diseases Control and PreventionXinyang 464000People’s Republic of China The 990 Hospital of Chinese People’s Liberation Army Joint Logistic Support ForceXinyang 464000Peo‑ple’s Republic of China Department of EpidemiologyMinistry of Education Key Lab of Hazard Assessment and Control in Special Operational Environ‑mentSchool of Public HealthAir Force Medical UniversityXi’an 710032People’s Republic of China Department of BiostatisticsCollege of Public Health and Health Professionsand Emerging Pathogens InstituteUniversity of FloridaGainesvilleFL 32611USA 

出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)

年 卷 期：2021年第10卷第6期

页      面：74-82页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：This work was supported by the China Mega-project for Infectious Diseases(2018ZX10713002 and 2018ZX10301401) Natural Science Foundation of China(81825019 and 82073617) Peking University Medicine Fund of Fostering Young Scholars’ Scientific and Technological Innovation 

主　　题：Severe fever with thrombocytopenia Serological study Healthy participant IgG antibody Neutralizing antibody 

摘      要：Background: Severe fever with thrombocytopenia (SFTS) caused by SFTS virus (SFTSV) was a tick-borne hemorrhagic fever that posed significant threat to human health in Eastern Asia. The study was designed to measure the seroprevalence of SFTSV antibody in healthy population residing in a high endemic ***: A cohort study was performed on healthy residents in Shangcheng County in Xinyang City from April to December in 2018, where the highest SFTS incidence in China was reported. Anti-SFTSV IgG was measured by indirect enzyme-linked immunosorbent assay and neutralizing antibody (NAb) was detected by using PRNT50. The logistic regression models were performed to analyze the variables that were associated with seropositive ***: Totally 886 individuals were recruited. The baseline seroprevalence that was tested before the epidemic season was 11.9% (70/587) for IgG and 6.8% (40/587) for NAb, which was increased to 13.4% (47/350) and 7.7% (27/350) during the epidemic season, and further to 15.8% (80/508) and 9.8% (50/508) post epidemic. The IgG antibody-based seropositivity was significantly related to the patients aged ≥ 70 years old [adjusted odds ratio (OR) = 2.440, 95% confidence interval (CI): 1.334-4.461 compared to the group of 50 years old,P = 0.004], recent contact with cats (adjustedOR = 2.195, 95%CI: 1.261-3.818,P = 0.005), and working in tea garden (adjustedOR = 1.698, 95%CI: 1.002-2.880,P = 0.049) by applying multivariate logistic regression model. The NAb based seropositivity was similarly related to the patients aged ≥ 70 years old (adjustedOR = 2.691, 95%CI: 1.271-5.695 compared to the group of 50 years old,P = 0.010), and recent contact with cats (OR = 2.648, 95%CI: 1.419-4.941,P = 0.002). For a cohort of individuals continually sampled with 1-year apart, the anti-SFTSV IgG were maintained at a stable level, while the NAb level ***: Subclinical infection might not provide adequate immunity to protect reinfection of SF