Epigenetic regulation of energy metabolism in obesity
作者机构：Department of GeriatricsSir Run Run HospitalNanjing Medical UniversityNanjing 211166China Key Laboratory for Aging&DiseaseNanjing Medical UniversityNanjing 211166China Department of MedicinePhysiology and BiophysicsUC Irvine Diabetes CenterUniversity of California IrvineIrvineCA 92697USA
出 版 物：《Journal of Molecular Cell Biology》 (分子细胞生物学报（英文版）)
年 卷 期：2021年第13卷第7期
页 面：480-499页
核心收录：
学科分类：0710[理学-生物学] 07[理学] 071007[理学-遗传学]
基 金：supported by grants from the National Institutes of Health(NIH,R01 DK121146)to Q.Y. the National Natural Science Foundation of China(81970218 and 81770440 to X.L.,81970217 and 81700331 to W.G.) the jiangsu Province Health Development Project with Science and Education(QNRC2016857 to W.G.) the Six One Project of Jiangsu Province(LGY2018100 to W.G.) the Six Talent Peaks Project of Jiangsu Province(WSN-175 to W.G.).
主 题：obesity epigenetics energy metabolism treatment
摘 要：Obesity has reached epidemic proportions globally.Although modern adoption of a sedentary lifestyle coupled with energy-dense nutrition is considered to be the main cause of obesity epidemic,genetic preposition contributes significantly to the imbalanced energy metabolism in obesity.However,the variants of genetic loci identified from large-scale genetic studies do not appear to fully explain the rapid increase in obesity epidemic in the last four to five decades.Recent advancements of next-generation sequencing technologies and studies of tissue-specific effects of epigenetic factors in metabolic organs have significantly advanced our understanding of epigenetic regulation of energy metabolism in obesity.The epigenome,including DNA methylation,histone modifications,and RNA-mediated processes,is characterized as mitotically or meiotically heritable changes in gene function without alteration of DNA sequence.Importantly,epigenetic modifications are reversible.Therefore,comprehensively understanding the landscape of epigenetic regulation of energy metabolism could unravel novel molecular targets for obesity treatment.In this review,we summarize the current knowledge on the roles of DNA methylation,histone modifications such as methylation and acetylation,and RNA-mediated processes in regulating energy metabolism.We also discuss the effects of lifestyle modifications and therapeutic agents on epigenetic regulation of energy metabolism in obesity.
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