Development of novel agents based on nitric oxide for the control of colon cancer

作     者：Vassiliki KOZONI Theophilos ROSENBERG Basil RIGAS 

作者机构：Division of Cancer PreventionStony Brook University Stony BrookNY 11794-5200USA First Department of Surgery Laikon HospitalAthens University11527 AthensGreece 

出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))

年 卷 期：2007年第28卷第9期

页      面：1429-1433页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by a NIH 2R01 CA92423 grant 

主　　题：nitric oxide-donating NSAIDs nitric oxide aspirin colon cancer chemoprevention nitric oxide 

摘      要：Nitric oxide-donating nonsteroidal anti-inflammatory drugs (NO-NSAIDs) repre-sent a novel class of compounds that hold promise as agents for the control ofcolon *** are derivatives of conventional NSAIDs that have been modi-fied by adding to them,via a spacer molecule,a nitric oxide releasing *** is that the combined effects of NO and the NSAID moiety will exceedthose of each structural component *** work has demonstrated theirpotency and efficacy in preclinical models of colon *** mechanism ofaction of NO-NSAIDs involves the modulation of several critical cellular signalingpathways,whereas the induction of a state of oxidative stress,at least by NO-aspirin,appears to be a major proximal *** trials are needed to assessthe role of NO-NSAIDs in the control of colon cancer.