Cancer Susceptibility for Male Breast Cancer Assessed by SNP-A Analysis and Risk Alleles of <i>TP</i>53, <i>MDM</i>2, <i>VEGF</i>, <i>VEGFR</i>1, <i>HIF</i>1<i>A</i>and <i>BRCA</i>1

作     者：Sarika Sharma Vasudha Sambyal Kamlesh Guleria Ruhi Kapahi Neeti Rajan Singh Mridu Manjari Sarika Sharma;Vasudha Sambyal;Kamlesh Guleria;Ruhi Kapahi;Neeti Rajan Singh;Mridu Manjari

作者机构：Human Cytogenetics Laboratory Guru Nanak Dev University Amritsar India Department of Surgery Sri Guru Ram Das Institute of Medical Sciences and Research Amritsar India Department of Pathology Sri Guru Ram Das Institute of Medical Sciences and Research Amritsar India 

出 版 物：《Advances in Breast Cancer Research》 (乳腺癌（英文）)

年 卷 期：2021年第10卷第4期

页      面：218-233页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Breast Cancer Aneuploidy Polymorphism CN-LOH SNP-A 

摘      要：Male Breast Cancer (MBC) has a familial component thus identification of polymorphic risk alleles of candidate genes and/or cytogenetic anomalies may help to predict the risk for the offspring of MBC patients. The conventional metaphase cytogenetics can indicate loci that are hotspots while analysis by single nucleotide polymorphism arrays (SNP-A) can identify chromosomal defects which may play a role in the etiology of cancer. A cumulative genotype risk due to each allele of candidate genes of the signaling pathways regulating c-MYC, HIF1A, TP53 and BRCA1 may be a factor facilitating cancer development. Cancer risk was assessed in a 35-year-old healthy son of a 60-year-old MBC patient with a family history of cancer by metaphase cytogenetics, SNP-A and analysis of 25 polymorphisms in six genes TP53, MDM2, VEGF,span style=font-famil