Multifunctional polyethyleneimine for synthesis of core-shell nanostructures and electrochemiluminescent detection of three AMI biomarkers

作     者：Xu Liang Lan Mi Zhengyou Yu Minghan Wang Yuecong Hu Xinhe Zheng Yi Shao Zhiwei Zhu Yuanhua Shao Xu Liang;Lan Mi;Zhengyou Yu;Minghan Wang;Yuecong Hu;Xinhe Zheng;Yi Shao;Zhiwei Zhu;Yuanhua Shao

作者机构：Beijing National Laboratory for Molecular SciencesCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing100871China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2021年第64卷第12期

页      面：2230-2238页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 0817[工学-化学工程与技术] 1010[医学-医学技术（可授医学、理学学位）] 070302[理学-分析化学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 10[医学] 0702[理学-物理学] 

基　　金：supported by the National Key Research and Development Program of China(2016YFA0201300) the National Natural Science Foundation of China(22034001) Beijing National Laboratory for Molecular Sciences(BNLMS-CXXM-202008) 

主　　题：simplicity multifunction branched polyethylenemine electrochemiluminescence AMI biomarkers 

摘      要：Simplicity and stability of an analytical method are the key to practical *** order to achieve such a goal,a molecule with multifunction could be one of the *** this work,the multifunctional characteristics of branched polyethylenemine(bPEI)were employed for verification of this *** types of amines in the bPEI can be used to synthesize core-shell nanostructures(bPEI@Au and SiO_(2)@bPEI@Au)in a simple one-pot process within 1 h,and as coreactants with over 500-fold enhancement for electrochemiluminescent(ECL)*** on the remarkable performance of bPEI,a label-free ECL immunosensor and its array with the same assembly strategy were constructed for the simple and rapid determination of three acute myocardial infarction(AMI)biomarkers:cardiac troponin I(cTnI),human-type fatty acid binding protein(hFABP)and *** methods exhibited excellent stability and sensitivity with wide linear range and low limits of detection down to fg/mL level by the photomultiplier tube and pg/mL level by the electron-multiplying charge-coupled device.