Diagnosis and treatment of primary pulmonary enteric adenocarcinoma:Report of Six cases
作者机构：Department of Respiratory MedicineThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2021年第9卷第30期
页 面：9236-9243页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by Medicine and Health Project of Zhejiang Province China No.2018KY049
主 题：Pulmonary enteric adenocarcinoma Immunohistochemistry Diagnosis Treatment KRAS Case report
摘 要：BACKGROUND Primary pulmonary enteric adenocarcinoma(PEAC)is a very rare subtype of invasive adenocarcinoma,and there have been no large studies on PEAC to ***,it is necessary to obtain much more information about the clinical and pathological features,diagnosis,differential diagnosis,and treatment of *** SUMMARY All clinical data of six patients with confirmed PEAC from 2013 to 2018 were collected,and data on diagnosis,differential diagnosis,and treatment of PEAC are discussed combined with all the associated *** mean age of six patients was 64.0±5.6(59-73)years *** clinical manifestations were heterogeneous,and during their disease course,there were no gastrointestinal *** was no evidence from colonoscopy or imaging studies to suggest digestive tract tumors or new *** most commonly mutated gene was KRAS(50.0%),and the pathological features of the six cases were similar to those of colorectal ***2(83.3%)and CK7(66.7%)had the highest positive rates upon immunohistochemical *** the associated literature,252 cases were identified,and the most commonly mutated gene was KRAS(42.9%).Additionally,CDX2(68.3%)and CK7(85.8%)had the highest positive *** mainly received surgery,chemotherapy,and radiotherapy,immunotherapy was not *** Positive results for CDX2 and CK7 play an important role in the diagnosis and differential diagnosis of PEAC,and immunotherapy or targeted therapy focused on KRAS needs to be further studied for the treatment of PEAC.
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