The Steric Effect of trans-(1S,2S)-1-Substituted-2-(N,N-dialkyl-amino)-1-indanol Derivatives as Chiral Ligands in the Catalytic Enantioselective Addition of Diethylzinc to Aldehydes

作     者：Qian Yong XU Hong Fang YANG Xin Fu PAN Guang Ming ZHU 

作者机构：Northwest Institute of Nuclear TechnologyP.O.Box 69Xi'an 710024 Department of ChemistryNational Laboratory of Applied Organic ChemistryLanzhou UniversityLanzhou 730000 Department of Chemical EngineeringNorthwestern Polytechnic UniversityXi'an 710062 

出 版 物：《Chinese Chemical Letters》 (中国化学快报(英文版))

年 卷 期：2002年第13卷第11期

页      面：1029-1032页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

主　　题：Diethylzinc enantioselective alkylation indanol derivative. 

摘      要：Optically active trans-(1S,2S)-1-substituted-2-(N,N-dialkylamino)-1-indanol derivatives have been prepared and used in the asymmetric addition of diethylzinc to aldehydes to give sec-alcohol in good yield with up to 93.1% enantiomeric excess.