Natural antioxidants in the management of Parkinson's disease: Review of evidence from cell line and animal models

作     者：Reem Abdul-Latif Ieva Stupans Ayman Allahham Benu Adhikari Thilini Thrimawithana Reem Abdul-Latif;Ieva Stupans;Ayman Allahham;Benu Adhikari;Thilini Thrimawithana

作者机构：Discipline of PharmacySchool of Health and Biomedical SciencesRoyal Melbourne Institute of Technology UniversityBundooraVIC 3084Australia Biosciences and Food TechnologySchool of ScienceRoyal Melbourne Institute of Technology UniversityBundooraVIC 3084Australia 

出 版 物：《Journal of Integrative Medicine》 (结合医学学报（英文版）)

年 卷 期：2021年第19卷第4期

页      面：300-310页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1005[医学-中医学] 1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：Parkinson’s disease Neurodegeneration Antioxidants Plant Alternative and complementary medicine 

摘      要：Parkinson’s disease(PD) is a chronic progressive neurodegenerative disease. It results from the death of dopaminergic neurons. The pathophysiological mechanisms in idiopathic PD include the production of α-synuclein and mitochondrial respiratory function-affecting complex I, caused by reactive oxygen species.Therefore, the use of natural antioxidants in PD may provide an alternative therapy that prevents oxidative stress and reduces disease progression. In this review, the effects of hydroxytyrosol, Ginkgo biloba,Withania somnifera, curcumin, green tea, and Hypericum perforatum in PD animal and cell line models are compared and discussed. The reviewed antioxidants show evidence of protecting neural cells from oxidative stress in animal and cell models of PD. However, the clinical efficacy of these phytochemicals needs to be optimised and further investigated.