Exosomal long non-coding RNAs:Emerging players in cancer metastasis and potential diagnostic biomarkers for personalized oncology
作者机构：Department of PathologyXiangya HospitalCentral South UniversityChangshaHunan Province410008PR China Department of Rheumatology and ImmunologyXiangya HospitalCentral South UniversityChangshaHunan Province410008PR China National Clinical Research Center for Geriatric DisordersXiangya HospitalCentral South UniversityChangshaHunan Province410008PR China
出 版 物：《Genes & Diseases》 (基因与疾病（英文）)
年 卷 期：2021年第8卷第6期
页 面：769-780页
核心收录：
学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 0703[理学-化学] 10[医学]
基 金：This study was supported by the National Natural Science Foundation of China[grant number 81903032] the National Key Research and Development Program of China[grant number 2016YFC1201800] the China Postdoctoral Science Foundation[grant number 2020M672520] the Youth Fund of Xiangya Hospital[grant number 2018Q011] the Mittal Innovative Entrepreneurial Project of Central South University[grant number XCX20190719].
主 题：Cancer metastasis Exosomes Extracellular vesicles Long noncoding RNA Therapy Tumor marker
摘 要：Metastasis is a major challenge in the treatment of cancer.Exosomes are a class of small extracellular vesicles(EVs)that play critical roles in several human diseases,especially cancer,by transferring information(e.g.,DNA,RNA,and protein)via cell-to-cell communication.Numerous recent studies have shown that exosomal long non-coding RNAs(lncRNAs)play crucial regulatory roles in cancer metastasis in the tumor microenvironment by altering the expression of several key signaling pathways and molecules.Due to their specificity and sensitivity,exosomal lncRNAs have potential as novel tumor markers and therapeutic targets in the treatment of cancer metastasis.In this review,we aim to summarize the roles of exosomal lncRNAs in cancer metastasis,the mechanisms underlying their roles,and their potential clinical applications.
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