Clinical Oncology Translational Study Phase-1 with Antitumor Phosphorylethanolamine(2-AEH_(2)P)in Dogs with Neoplasms

作     者：Olivia Gonçalves de Almeida Leitão da Cunha Lucas Campos de SáRodrigues Daniel da Conceição Rabelo Rosa Andrea Nogueira Laiso Sergio Mestieri Chammas Laertty Garcia de Sousa Cabral Durvanei Augusto Maria 

作者机构：Development and Innovation LaboratoryButantan InstituteAvenue Vital Brasil1500Sao Paulo 05503-900Brazil Faculty of Veterinary Medicine and Animal ScienceSao Paulo UniversitySao Paulo 01246-000Brazil Veretinary Hospital EstimaAvenue Granadeiro GuimaraesTaubaté155Sao PauloBrazil Faculty of Medicine of the University of São PauloSão Paulo 01246-000Brazil 

出 版 物：《Journal of Pharmacy and Pharmacology》 (药剂与药理学（英文版）)

年 卷 期：2021年第9卷第5期

页      面：179-196页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq).Durvanei Augusto Maria-Process number 305056/2019-0 

主　　题：Cancer metabolism phospholipids monophosphoester Fibonacci Model clinical study. 

摘      要：The animal has the potential to serve as a clinical model for human disease,due to striking similarities and homologies in *** clinical development of a new drug may influence its final destination,and a careful and thoughtful approach to Phase-1 clinical trials is ***(2-AEH2P)is a new cytostatic phospholipid agent that,unlike most chemotherapeutic drugs used today,does not target DNA or cytoskeleton,but act on the cell *** carried out by our group have shown several effects of 2-AEH2P controlling the progression of the cell cycle,in the alterations of the mitochondrial electrical potential capable of inducing apoptosis and autophagy in several types of human and animal tumor *** aim of this study is to establish the recommended safety dose of a 2-AEH2P monophosphoester,in dogs with tumor following the Phase 1 study model proposed by *** Phase-1 study following the Fibonacci model,2-AEH2P was safe at all staggered doses up to 150 mg/Kg for 8 *** administration in staggered doses according to the Fibonacci model,showed that the drug is safe,no advent of mortality during the study period or acute toxicity were *** is not a drug with hemolytic properties or that induces *** does not lead to changes in liver and renal functions and was able to modulate leukocyte production.2-AEH2P is new compound with antitumor potential,being useful for future veterinary and human tumors,as a combination of chemotherapeutic agents.