Fecal DNA testing for colorectal cancer screening:molecular targets and perspectives

作     者：Amaninder Dhaliwal Panagiotis J Vlachostergios Katerina G Oikonomou Yitzchak Moshenyat 

作者机构：Department of MedicineNYU Lutheran Medical Center Division of GastroenterologyNYU Lutheran Medical Center 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2015年第7卷第10期

页      面：178-183页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Colorectal cancer Screening Fecal DNA Cologuard^(■) Adenoma 

摘      要：The early detection of colorectal cancer with effective screening is essential for reduction of cancer-specific mortality. The addition of fecal DNA testing in the armamentarium of screening methods already in clinical use launches a new era in the noninvasive part of colorectal cancer screening and emanates from a large number of previous and ongoing clinical investigations and technological advancements. In this review, we discuss the molecular rational and most important genetic alterations hallmarking the early colorectal carcinogenesis process. Also, representative DNA targets-markers and key aspects of their testing at the clinical level in comparison or/and association with other screening methods are described. Finally, a critical view of the strengths and limitations of fecal DNA tests is provided, along with anticipated barriers and suggestions for further exploitation of their use.