Understanding autism spectrum disorders with animal models:applications,insights,and perspectives

作     者：Zhu Li Yuan-Xiang Zhu Li-Jun Gu Ying Cheng Zhu Li;Yuan-Xiang Zhu;Li-Jun Gu;Ying Cheng

作者机构：Institute of Biomedical ResearchYunnan UniversityKunmingYunnan 650500China 

出 版 物：《Zoological Research》 (动物学研究（英文）)

年 卷 期：2021年第42卷第6期

页      面：800-824页

核心收录：

学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：This work was supported by the National Natural Science Foundation of China(82071540)and Yunnan University(CZ21623201) 

主　　题：Autism spectrum disorders Animal models Neurodevelopment Genetics Environment 

摘      要：Autism spectrum disorder(ASD)is typically characterized by common deficits in social skills and repetitive/stereotyped *** is widely accepted that genetic and environmental factors solely or in combination cause ***,the underlying pathogenic mechanism is unclear due to its highly heterogeneous *** better understand the pathogenesis of ASD,various animal models have been generated,which can be generally divided into genetic,environment-induced,and idiopathic animal *** this review,we summarize the common animals used for ASD study and then discuss the applications,clinical insights,as well as challenges and prospects of current ASD animal models.