Antibody neutralization to SARS-CoV-2 and variants after 1 year in Wuhan,China
作者机构：State Key Laboratory of VirologyInstitute for Vaccine Research and Modern Virology Research CenterCollege of Life SciencesWuhan UniversityWuhan 430072China Hubei Provincial Center for Disease Control and PreventionWuhan 430079China Wuhan Jiang’an District Center for Disease Control and PreventionWuhan 430000China National Virus Resource CenterWuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China Guangdong Provincial Center for Disease Control and PreventionGuangzhou 511430China
出 版 物：《The Innovation》 (创新（英文）)
年 卷 期：2022年第3卷第1期
页 面：1-8页
核心收录：
学科分类：0202[经济学-应用经济学] 02[经济学] 020205[经济学-产业经济学]
基 金：supported by grants from the National Science and Technology Major Project(2018YFA0900801) China NSFC projects(32041007,32070160,and 82041004) Fundamental Research Funds for the Central Universities(2042021kf0220 and 2042020kf0024) the Advanced Customer Cultivation Project of Wuhan National Biosafety Laboratory(2021ACCP-MS10) Special Fund for COVID-19 Research of Wuhan University
主 题：immunity maintained maintain
摘 要：Most COVID-19 convalescents can build effective anti-SARS-CoV-2 humoral immunity,but it remains unclear how long it can maintain and how efficiently it can prevent the reinfection of the emerging SARS-CoV-2 ***,we tested the sera from 248 COVID-19 convalescents around 1 year post-infection in Wuhan,the earliest known ***-CoV-2 immunoglobulin G(IgG)was well maintained in most patients and potently neutralizes the infection of the original strain and the B.1.1.7 ***,varying degrees of immune escape was observed on the other tested variants in a patient-specific manner,with individuals showing remarkably broad neutralization *** immune escape can be largely attributed to several critical spike *** results suggest that SARS-CoV-2 can elicit long-lasting immunity but this is escaped by the emerging variants.
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