Diagnostic accuracy of dynamic contrast-enhanced magnetic resonance imaging for distinguishing pseudoprogression from glioma recurrence:a meta-analysis

作     者：Jun Qiu Zhen-Chao Tao Ke-Xue Deng Peng Wang Chuan-Yu Chen Fang Xiao Yi Luo Shu-Ya Yuan Hao Chen Huan Huang Jun Qiu;Zhen-Chao Tao;Ke-Xue Deng;Peng Wang;Chuan-Yu Chen;Fang Xiao;Yi Luo;Shu-Ya Yuan;Hao Chen;Huan Huang

作者机构：Department of RadiologyThe First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230036China Department of Radiation OncologyThe First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230036China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2021年第134卷第21期

页      面：2535-2543页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1002[医学-临床医学] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 100214[医学-肿瘤学] 10[医学] 

主　　题：Meta-analysis Dynamic contrast-enhanced magnetic resonance imaging Pseudoprogression Diagnostic accuracy Glioma 

摘      要：Background:It is crucial to differentiate accurately glioma recurrence and pseudoprogression which have entirely different prognosis and require different treatment *** study aimed to assess the diagnostic accuracy of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)as a tool for distinguishing glioma recurrence and ***:According to particular criteria of inclusion and exclusion,related studies up to May 1,2019,were thoroughly searched from several databases including PubMed,Embase,Cochrane Library,and Chinese biomedical *** quality assessment of diagnostic accuracy studies was applied to evaluate the quality of the included *** using themadapackage in R,the heterogeneity,overall sensitivity,specificity,and diagnostic odds ratio were ***,funnel plots were used to visualize and estimate the publication bias in this *** area under the summary receiver operating characteristic(SROC)curve was computed to display the diagnostic efficiency of ***:In the present meta-analysis,a total of 11 studies covering 616 patients were *** results showed that the pooled sensitivity,specificity,and diagnostic odds ratio were 0.792(95%confidence interval[CI]0.707-0.857),0.779(95%CI 0.715-0.832),and 16.219(97.5%CI 9.123-28.833),*** value of the area under the SROC curve was *** addition,the SROC curve showed high sensitivities(0.6)and low false positive rates(0.5)from most of the included studies,which suggest that the results of our study were ***,the funnel plot suggested the existence of publication ***:While the DCE-MRI is not the perfect diagnostic tool for distinguishing glioma recurrence and pseudoprogression,it was capable of improving diagnostic ***,further investigations combining DCE-MRI with other imaging modalities are required to establish an efficient diagnostic method for glioma patients.