How to package and SEND mRNA: a novel “humanized” vector system based on endogenous retroviruses

作     者：Kristoffer Riecken Dawid Głów Boris Fehse Kristoffer Riecken;Dawid Głów;Boris Fehse

作者机构：Research Dept.Cell&Gene TherapyDept.of Stem Cell TransplantationUniversity Medical Centre Hamburg-Eppendorf(UKE)Hamburg 20246Germany 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2021年第6卷第12期

页      面：3367-3368页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 0836[工学-生物工程] 

基　　金：This work has been supported by the Deutsche Forschungsgemeinschaft(DFG)within SFB841/SP2(80750187) 

主　　题：endogenous system entirely 

摘      要：A recent publication in Science describes a novel mRNA delivery system termed SEND,entirely consisting of endogenous proteins.1 These virus-like particles(VLPs),able to deliver mRNA of e.g.,Cas9,represent a new class of gene transfer *** development of efficient,specific,and safe vectors for the delivery of nucleic acids and proteins remains one of the biggest challenges in gene therapy,particularly for in vivo *** currently preferred viral vectors have several limitations,including biosafety issues,laborious and expensive manufacture,as well as the impossibility of multiple applications due to the inherent immunogenicity of viral *** contrast,non-viral vectors are much easier to produce on a large scale,but have not yet reached gene transfer rates comparable with viral vectors.