Radical cystoprostatectomy with orthotopic neobladder for a case of treatment emergent neuroendocrine prostate cancer presenting as bladder mass with hematuriaea rare instance of tumor remission after local control

作     者：Rahul Jena Hira Lal Nandita Chaudhary 

作者机构：Uday Pratap Singh Department of Urology and Renal TransplantSanjay Gandhi Postgraduate Institute of Medical SciencesLucknowIndia Department of RadiodiagnosisSanjay Gandhi Postgraduate Institute of Medical SciencesLucknowIndia Department of PathologySanjay Gandhi Postgraduate Institute of Medical SciencesLucknowIndia 

出 版 物：《Asian Journal of Urology》 (亚洲泌尿外科杂志（英文）)

年 卷 期：2021年第8卷第4期

页      面：444-447页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：bladder diagnosis chemotherapy 

摘      要：Dear editor Treatment emergent neuroendocrine prostate cancer(tNEPC)is most commonly observed after development of resistance to androgen deprivation therapy(ADT)and is associated with rapid progression and widespread metastases with survival less than 1 year from diagnosis[1].Management of this disease is mainly through cytotoxic chemotherapy and there is no published evidence of treating the primary prostatic lesion in this stage of the disease,unlike that of localized prostate cancer or castrate sensitive metastatic prostate cancer[2].In this letter,we report the only known case of t-NEPC who presented with an initial diagnosis of bladder urothelial carcinoma and was treated by early radical surgery and chemotherapy,which led to longterm disease control and preservation of quality of life.